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KMID : 0378019850280080123
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New Medical Journal
1985 Volume.28 No. 8 p.123 ~ p.130
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Clinical experience of Piroxicam 0.5% Gel in a topical formulation with patients with Rheumatoid Arthritis, Osteoarthritis, and Acute Musculoskeletal Disorders
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Lee, Chang-Joo/이창주
Im, Sun/Chang, Sung Kee/Lee, Jin Soo/이선/장성기/이진수
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Abstract
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A clinical experience to assess the efficacy of Piroxicam 0. 5% Gel on the patients with Rheumatoid Arthritis, Osteoarthritis or Acute musculoskeletal Disorders had been undertaken.
Fifty six patients had been treated with the Piroxicam ointment for four weeks. 2.0~4.0 gm of the ointment was daily applied for each patient topically to the skin around the affected joints for four weeks.
The patients had been evaluated at the 2 and 4 weeks of use, respectively. No side effect of the ointment was found in our patients so long as the testing period. The changes in the parameters like both pains at rest and on motion, tenderness, and swelling were much reduced in almost all the patients, especially on the 2nd week evaluation. There no significant differences of efficacy among the joints involved, regardless of superficial or deep.
A couple of cases were satisfied with their acute symptoms subsided in the first three or four days of use.
Results were as follows:
1. Distribution by disease entities showed 27 cases of Rheumatoid Arthritis, 14 cases of. Osteoarthritis, and 15 cases of Acute Musculoskeletal Disorders.
2. Distribution by the involved joints showed 6 of deep joints such as shoulder (3), hip (1), and back (2), with contrast to 44 superficial joints such as elbow (5), wrist(7), hand (6), knee (22), ankle (3), and foot (1).
3. Changes in clinical symptoms and signs responding to Piroxicam demonstrated marked reduction of the mean scores in the 2nd week assessment.
4 Severe degrees of clinical symptoms and signs were alleviated to decrease in number of the patients in the course of treatment.
In contrast, slight of none degrees increased in number of the patients due to the shift from moderate and severe degrees.
5. The 2 week assessment of efficacy on Rheumatoid Arthritis turned out 6(22.2%) to be excellent, 6(22.2%) good, 10(37.1%) fair, and 5(18.5%) poor. Instead, the 4th week evaluation showed 6(22.2%), 8(29.6%), 10(37.1%), and 3(11.1%) respectively, in consistent with rate.
The efficacy of Piroxicam ointment on Osteoarthritis demonstrated 1(7. 1%) excellent, 8. (57.2%) good, 5(35.7%) fair at 2 weeks of treatment.
The 4th week evaluation revealed 3(21.4%), 9(64.3%), 2(14.3%), in consistent with rate.
Acute Musculoskeletal Disorders were at 2 weeks of treatment calmed down to be 1(6.7%) of excellent, 8(53.3%) of good, 3(20%) of fair, and 3(20%) of poor results.
The 4th week results were 1(6.6%), 11(73.4%), and 3(20%) respectively, in consistent with rate.
6. Overall assessment of efficacy of the Piroxicam 0.5% Gel on the varieties of Arthritis was possible to be explained as that 38(67.9%) out of 56 patients treated for 4 weeks were excellent or good.
So far as our experiment was performed not any side effect has been found, and every patient has been tolerable with the piroxicam 0.5% .gel.
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